Volume 87, Issue 6, Pages 1223-1229 (June 2015) Tubulointerstitial nephritis is a dominant feature of hereditary apolipoprotein A-I amyloidosis  Gina Gregorini, Claudia Izzi, Pietro Ravani, Laura Obici, Nadia Dallera, Andrea Del Barba, Alessandro Negrinelli, Regina Tardanico, Matilde Nardi, Luciano Biasi, Tiziano Scalvini, Giampaolo Merlini, Francesco Scolari  Kidney International  Volume 87, Issue 6, Pages 1223-1229 (June 2015) DOI: 10.1038/ki.2014.389 Copyright © 2015 International Society of Nephrology Terms and Conditions

Figure 1 Clinical manifestations: prevalence data (%) by age, category, and gender. Kidney International 2015 87, 1223-1229DOI: (10.1038/ki.2014.389) Copyright © 2015 International Society of Nephrology Terms and Conditions

Figure 2 Histological findings in target organs. (a) Kidney biopsy specimen: peritubular and interstitial amyloid deposition in the medulla (periodic acid–Schiff stain). (b) Kidney biopsy specimen: nodular aggregate of amyloid in the inner medulla (periodic acid–Schiff stain). (c) Liver biopsy specimen: large amyloidotic area in portal areas (hematoxylin-eosin stain). (d) Testicular biopsy specimen: massive peritubular deposition of amyloid material. Magnification × 20 (a–d: scale bars=100 μm). Kidney International 2015 87, 1223-1229DOI: (10.1038/ki.2014.389) Copyright © 2015 International Society of Nephrology Terms and Conditions

Figure 3 Cumulative risk of progression of Apo-AI disease. Y-axis is the cumulative risk of clinically relevant end points; x-axis is time in years since the first organ-specific manifestation. ESRD, end-stage renal disease. Kidney International 2015 87, 1223-1229DOI: (10.1038/ki.2014.389) Copyright © 2015 International Society of Nephrology Terms and Conditions

Figure 4 Cumulative risk of progression of Apo-AI disease. Y-axis is the cumulative risk of clinically relevant end points; x-axis is age in years from birth. ESRD, end-stage renal disease. Kidney International 2015 87, 1223-1229DOI: (10.1038/ki.2014.389) Copyright © 2015 International Society of Nephrology Terms and Conditions