It’s ALL in the Family: IKZF1 and Hereditary Leukemia

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It’s ALL in the Family: IKZF1 and Hereditary Leukemia Junne Kamihara, Akiko Shimamura Cancer Cell Volume 33, Issue 5, Pages 798-800 (May 2018) DOI: 10.1016/j.ccell.2018.04.008 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 IKZF1 Germline and Somatic Mutations (A) IKZF1 structural domains and mutations (top), modified from Churchman et al. (2018), and functional assays used by Churchman et al. to assess pathogenicity of identified IKZF1 variants (bottom). (B) Germline IKZF1 mutations are associated with immunodeficiency and predisposition to B cell leukemia. Acquisition of somatic mutations in IZKF1 also promote the development of B cell leukemia. HSC, hematopoietic stem cell. Figure 1B modified from https://pixabay.com/en/man-user-profile-person-icon-42934/. Cancer Cell 2018 33, 798-800DOI: (10.1016/j.ccell.2018.04.008) Copyright © 2018 Elsevier Inc. Terms and Conditions