A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P = <0.0001; HER2.

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A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P = <0.0001; HER2 2+ cell lines, P = <0.0001; and HER2 1+ cell lines, P = <0.0001) at 3 days. A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P = <0.0001; HER2 2+ cell lines, P = <0.0001; and HER2 1+ cell lines, P = <0.0001) at 3 days. B, cytotoxicity in representative HER2 3+, 2+, and 1+ USC cell lines after 3 and 6 days exposure to 2.0 μg/mL of ADC SYD985 versus T-DM1. Jonathan Black et al. Mol Cancer Ther 2016;15:1900-1909 ©2016 by American Association for Cancer Research