Lower SNS activity in WAT of fasted Ugcgf/f//CamKCreERT2 mice.

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Lower SNS activity in WAT of fasted Ugcgf/f//CamKCreERT2 mice. Lower SNS activity in WAT of fasted Ugcgf/f//CamKCreERT2 mice. A: NE content/milligram WAT is decreased in fasted Ugcgf/f//CamKCreERT2 mice (n = 3–7). B: When normalized to WAT protein content in order to account for different WAT cell sizes of fasted mouse groups, NE content is still decreased (n = 3–7). C: Schematic outline of BRL-stimulated in vitro lipolysis. Parametrial WAT is incubated in DMEM containing 50 ng/mL BRL, and supernatant samples are taken at the indicated time points for measurements of FFA. D: BRL-induced release of FFA is not significantly altered in WAT explants of Ugcgf/f//CamKCreERT2 mice (n = 5). E: Unchanged levels of β3-AR in WAT of Ugcgf/f//CamKCreERT2 mice (n = 7–9). This analysis was performed with mice 9 weeks pi. Mice were analyzed 6 weeks pi, unless stated otherwise. Data are reported as the mean ± SEM. *P ≤ 0.05, ***P ≤ 0.001. n.s., not significant. Silke Herzer et al. Diabetes 2015;64:3363-3376 ©2015 by American Diabetes Association