Palmar Bullous Blistering Induced by Erlotinib

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Palmar Bullous Blistering Induced by Erlotinib Arne Berg, MD, PhD, Odd Terje Brustugun, MD, PhD, Marius Lund-Iversen, MD, Åslaug Helland, MD, PhD  Journal of Thoracic Oncology  Volume 6, Issue 5, (May 2011) DOI: 10.1097/JTO.0b013e318211136b Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Acute onset of palmar bullous dermatitis 23 days after the start of erlotinib. Picture taken on day 25, 2 days after the first appearance. Photo courtesy: Per Marius Didriksen, Oslo University Hospital. Journal of Thoracic Oncology 2011 6, DOI: (10.1097/JTO.0b013e318211136b) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Histological biopsy showing intraepidermal bullae of varying size (squares), spongiosis (long red arrow), subepithelial edema (short red arrow), and a dermal leukocytic infiltrate composed of lymphocytes and plasma cells (long black arrow), and eosinophils (short black arrow), consistent with a bullous drug reaction. Photo courtesy: Marius Lund-Iversen, Oslo University Hospital. Journal of Thoracic Oncology 2011 6, DOI: (10.1097/JTO.0b013e318211136b) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions