Sustained response to mepolizumab in refractory Churg-Strauss syndrome

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity Andrei Malinovschi,

Advances in Diagnosing Peanut Allergy

Allergen immunotherapy: A practice parameter third update

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Clarification concerning amoxicillin skin testing

Antineutrophil cytoplasmic autoantibodies and myeloperoxidase autoantibodies in clinical expression of Churg-Strauss syndrome Bridget Healy, MBChB, Susan.

Fatty acids, inflammation, and asthma

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Dennis K. Ledford, MD, Sally Wenzel, MD

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Intramuscular Versus Intravenous Immunoglobulin Replacement Therapy and Measurement of Immunoglobulin Levels During Immunoglobulin Replacement Therapy

Fatty acids, inflammation, and asthma

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Rising prevalence of asthma is sex-specific in a US farming population

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Advances in Diagnosing Peanut Allergy

Nonadherence to Asthma Treatment: Getting Unstuck

Peter M. Wolfgram, MD, David B. Allen, MD

Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome Sophia Kim, MD, Gautham Marigowda, MD, Eyal Oren, MD, Elliot.

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

The Management of Eosinophilic Esophagitis

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

News Beyond Our Pages Journal of Allergy and Clinical Immunology

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Invasive fungal disease in autosomal-dominant hyper-IgE syndrome

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Sharon Seth, MD, David A. Khan, MD

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Hydroxyurea in the treatment of Churg-Strauss syndrome

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Hypereosinophilic syndrome: A multicenter, retrospective analysis of clinical characteristics and response to therapy Princess U. Ogbogu, MD, Bruce S.

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

One step forward, 2 steps back: The enigma of preschool wheeze

Development of Churg-Strauss syndrome with controlled asthma during omalizumab treatment Anne-Marie Ruppert, MD, Gerlinde Averous, MD, Daniela Stanciu,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Biology of nasal polyposis

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Measles and immunomodulation

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Pedro Giavina-Bianchi, MD, PhD, Shih-Wen Huang, MD

Albert Y. Wu, MD, Sanjiv Sur, MD, J. Andrew Grant, MD

Environmental factors and eosinophilic esophagitis

News & Notes Journal of Allergy and Clinical Immunology

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Safety and efficacy of repeated monthly carboplatin desensitization

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Presentation transcript:

Sustained response to mepolizumab in refractory Churg-Strauss syndrome Jean-Emmanuel Kahn, MD, Catherine Grandpeix-Guyodo, MD, Ibrahim Marroun, MD, Emilie Catherinot, MD, PhD, Francois Mellot, MD, Florence Roufosse, MD, PhD, Olivier Blétry, MD Journal of Allergy and Clinical Immunology Volume 125, Issue 1, Pages 267-270 (January 2010) DOI: 10.1016/j.jaci.2009.10.014 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Eosinophil count and prednisone dosage before and during mepolizumab treatment. Black arrows represent monthly pulses of cyclophosphamide, 1 g intravenous. Gray narrows represent infusion of mepolizumab, 750 mg intravenous. M, Month. Journal of Allergy and Clinical Immunology 2010 125, 267-270DOI: (10.1016/j.jaci.2009.10.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Computed tomography of the chest before mepolizumab (A) and 1 month (B) and 6 months (C) after mepolizumab initiation. Journal of Allergy and Clinical Immunology 2010 125, 267-270DOI: (10.1016/j.jaci.2009.10.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions