2010 Presidential Address: Culture: The Silent Language Geneticists Must Learn— Genetic Research with Indigenous Populations Roderick R. McInnes The.

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2010 Presidential Address: Culture: The Silent Language Geneticists Must Learn— Genetic Research with Indigenous Populations Roderick R. McInnes The American Journal of Human Genetics Volume 88, Issue 3, Pages 254-261 (March 2011) DOI: 10.1016/j.ajhg.2011.02.014 Copyright © 2011 Terms and Conditions

Figure 1 The Relationship between the Dominant Western Culture and an Indigenous Population (A) The view of our culture from the perspective of an indigenous culture. (B) The ideal equality of an indigenous culture's influence over research is represented by the arrows reaching to the full perimeter of the dominant culture's circle of influence. The American Journal of Human Genetics 2011 88, 254-261DOI: (10.1016/j.ajhg.2011.02.014) Copyright © 2011 Terms and Conditions

Figure 2 Long QT Syndrome in the Gitxsan Tribe of Northern British Columbia (A) The painting “Loon Representing Family Unit,” by the Gitxsan artist Virginia Morgan, depicts the mother loon with LQTS by a break in her heart, as well as in the heart of one of her two baby loons, who has inherited LQTS. The image represents the autosomal-dominant nature of the condition. (B) A simplified family pedigree of one index case family of Gitxsan, representing one of three kindreds from the same community with the V205M mutation in the KCNQ1 gene. The index case is indicated by an arrowhead. The presence of a V205M mutation confirmed by genotyping is designated by the filled symbols, and its absence by a horizontal line through the symbol. Unexplained death is designated with half-filled symbols with an oblique line designating death. Up to 1/100 Gitxsan individuals may carry the V205M mutation in the KCNQ1 gene (image reprinted with permission from Genetics in Medicine and originally published in Arbour et al.32). The American Journal of Human Genetics 2011 88, 254-261DOI: (10.1016/j.ajhg.2011.02.014) Copyright © 2011 Terms and Conditions

Roderick R. McInnes The American Journal of Human Genetics 2011 88, 254-261DOI: (10.1016/j.ajhg.2011.02.014) Copyright © 2011 Terms and Conditions