Cost-effectiveness plane for all PARTNER-B vs all ADVANCE and all PARTNER vs ADVANCE high risk comparisons with ICERs from five studies; dashed line represents willingness to pay of £20 000 per QALY gained (ICER, incremental cost-effectiveness ratio; MM, me... Cost-effectiveness plane for all PARTNER-B vs all ADVANCE and all PARTNER vs ADVANCE high risk comparisons with ICERs from five studies; dashed line represents willingness to pay of £20 000 per QALY gained (ICER, incremental cost-effectiveness ratio; MM, medical management; QALY, quality-adjusted life-years; CABG, coronary artery bypass graft; HF, heart failure; CRT, cardiac resynchronization therapy). Stephen Brecker et al. Open Heart 2014;1:e000155 ©2014 by British Cardiovascular Society