Fig. 7. Protein expression levels of BDNF, TrkB, p-CREB and p-ERK in the brain of rats after different treatments. 24 female Sprague–Dawley rats with ovariectomy.

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Sex Differences in Central Expression and Effects of Brain-Derived Neurotrophic Factor Haifei Shi Department of Biology, Miami University International.

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Fig. 7. Protein expression levels of BDNF, TrkB, p-CREB and p-ERK in the brain of rats after different treatments. 24 female Sprague–Dawley rats with ovariectomy underwent intraperitoneal administration of estrogen or its vehicle. 12 rats of sham-operated group only underwent the resection of a bit of fat around bilateral ovaries. Protein expression levels of BDNF, TrkB, p-CREB and p-ERK in the brain of rats after different treatments. 24 female Sprague–Dawley rats with ovariectomy underwent intraperitoneal administration of estrogen or its vehicle. 12 rats of sham-operated group only underwent the resection of a bit of fat around bilateral ovaries. All these rats were injected with 10 mg/kg NTG once a week and the injection was repeated five times. The rats were sacrificed during the migraine attacks (4 h after the fifth injection) or the headache-free intervals (24 h after the fifth injection). After rats were anaesthetized with ketamine and xylazine (i.p.), the whole brain was removed and subjected to RT-PCR assay. *P<0.05, **P<0.01 between each group (n=12, ANOVA followed by a Tukey's post hoc test for multiple comparisons). BDNF, brain-derived neurotrophic factor; TrkB, tropomyosin receptor kinases; p-ERK, phosphorylated extracellular signal-regulated kinase; p-CREB, phosphorylated c-AMP-responsive element binding protein. Jiu-Qing Guo et al. Biology Open 2017;6:8-16 © 2017. Published by The Company of Biologists Ltd