A-E: Bcl family gene regulation in human islets cultured in high versus normal glucose. A-E: Bcl family gene regulation in human islets cultured in high.

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A-E: Bcl family gene regulation in human islets cultured in high versus normal glucose. A-E: Bcl family gene regulation in human islets cultured in high versus normal glucose. Expression of Bcl-2, Bcl-xl, Bad, Bid, and Bik mRNA was detected by RT-PCR and quantified by FluorImager analysis of ethidium bromide signal. In each experiment, band densities were normalized against cyclophyllin, and the results are expressed as mRNA level to NG1 control islets (NG1 = 100%). A: Bcl-2. B: Bcl-xl (HG5 vs. NG5, **P < 0.01). C: Bad (HG5 vs. NG5, **P < 0.01). D: Bid (HG5 vs. NG5, ***P < 0.001). E: Bik (HG5 vs. NG5, **P < 0.01). One representative gel is also shown. Islets from six donors were analyzed. Means ± SD of relative expression of the genes are shown in bar graph. Statistical analysis was performed by ANOVA. Massimo Federici et al. Diabetes 2001;50:1290-1301 ©2001 by American Diabetes Association