Fig. 1 meR marks on E2F1 confer genome-wide effects.

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Fig. 1 meR marks on E2F1 confer genome-wide effects. meR marks on E2F1 confer genome-wide effects. (A) Schematic representation of E2F1, highlighting the region of the protein targeted by PRMT1 and PRMT5. The arginine methylation-defective E2F1 derivatives [R109K and R111/113 K (KK)] used to generate U2OS stable cell lines for RNA-seq analysis are also indicated (i). An immunoblot displaying E2F1 protein expression in U2OS stable cells after 24 hours of doxycycline (1 μg/ml) treatment is also included (ii). See also fig. S1 (A to D). (B) Venn diagrams showing the crossover of genes up- or down-regulated over twofold (adjusted P value threshold < 0.01) in each cell line condition with respect to the pTRE empty vector cell line, filtered for genes containing an E2F1 motif in their proximal promoter region (−900 to +100). These data were generated from three independent biological samples. Alice Poppy Roworth et al. Sci Adv 2019;5:eaaw4640 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).