SGLT 2 transporter mRNA (left) and protein (middle) and glucose transport (α-methyl-d-glucopyranoside) (right) are increased in cultured renal proximal.

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SGLT 2 transporter mRNA (left) and protein (middle) and glucose transport (α-methyl-d-glucopyranoside) (right) are increased in cultured renal proximal tubular epithelial cells of individuals with type 2 diabetes (T2DM) versus nondiabetic subjects (CON) (232). SGLT 2 transporter mRNA (left) and protein (middle) and glucose transport (α-methyl-d-glucopyranoside) (right) are increased in cultured renal proximal tubular epithelial cells of individuals with type 2 diabetes (T2DM) versus nondiabetic subjects (CON) (232). Ralph A. DeFronzo Diabetes 2009;58:773-795 ©2009 by American Diabetes Association