Volume 120, Issue 2, Pages 369-376 (February 2001) Gastric distention correlates with activation of multiple cortical and subcortical regions  Uri Ladabaum, Satoshi Minoshima, William L. Hasler, Donna Cross, William D. Chey, Chung Owyang  Gastroenterology  Volume 120, Issue 2, Pages 369-376 (February 2001) DOI: 10.1053/gast.2001.21201 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Pain, nausea, and bloating scores (mean ± SD) during distal gastric distention. Symptoms were rated on a scale from 0 to 5. Distending pressures during threshold pain (22 ± 8 mm Hg) and moderate pain (31 ± 8 mm Hg) were individualized for each subject in attempts to elicit pain scores of 1 and 2–3, respectively. *P < 0.002 compared with baseline with paired t test. Gastroenterology 2001 120, 369-376DOI: (10.1053/gast.2001.21201) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Color-coded statistical surface maps of cerebral regions activated during gastric distention under 4 conditions. Maps are superimposed on a reference normal brain magnetic resonance image transformed onto the stereotactic coordinates used in this study. Z scores ≥ 4.0 are considered significant. (A) Lateral and medial views of the right and left hemispheres. RT.LAT, right lateral; LT. LAT, left lateral; RT.MED, right medial; LT.MED, left medial. (B) Transverse brain slices at indicated levels above (positive distances) or below (negative distances) the reference plane from the anterior to the posterior commissure. ACC, anterior cingulate cortex; BS, brain stem; CA, caudate nucleus; CBL, cerebellum; INS, insula; OC, occipital cortex (including fusiform and lingual gyri, and cuneus); PFC, prefrontal cortex (activation not significant); THL, thalamus; VM, cerebellar vermis. Gastroenterology 2001 120, 369-376DOI: (10.1053/gast.2001.21201) Copyright © 2001 American Gastroenterological Association Terms and Conditions