Effects of the β-cell–specific expression of mKL on blood glucose levels, glucose tolerance, insulin sensitivity, and plasma insulin levels in STZ-induced.

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Effects of the β-cell–specific expression of mKL on blood glucose levels, glucose tolerance, insulin sensitivity, and plasma insulin levels in STZ-induced diabetic mice. 129S1/SvIm male mice were injected with PBS, rAAV-GFP, or rAAV-mKL, respectively. Effects of the β-cell–specific expression of mKL on blood glucose levels, glucose tolerance, insulin sensitivity, and plasma insulin levels in STZ-induced diabetic mice. 129S1/SvIm male mice were injected with PBS, rAAV-GFP, or rAAV-mKL, respectively. One week after gene delivery, these mice were injected with STZ or citrate buffer. Blood glucose levels, glucose tolerance, insulin sensitivity, and plasma insulin levels were measured during the 6-week period. Fasting blood glucose levels (A). GTT results at week 3 (B) and week 5 (D) after gene delivery. Area under the curve for GTT results at week 3 (C) and week 5 (E) after gene delivery. Original readings of IST results at week 6 (F) after gene delivery. Normalized blood glucose levels of IST results at week 6 (G) after gene delivery. Plasma insulin levels in mice at week 6 (H) after gene delivery. Urine glucose levels (I). Data are mean ± SEM. n = 4–6 animals/group. *P < 005, **P < 0.01, and ***P < 0.001 vs. the control (treated with PBS-citrate buffer) group; ++P < 0.01 and +++P < 0.001 vs. the PBS-STZ–treated group. Yi Lin, and Zhongjie Sun Diabetes 2015;64:4298-4311 ©2015 by American Diabetes Association