Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.

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Presentation transcript:

Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. (A) Marketed drugs containing free ─B(OH)2 moieties. (B) Common methods for late-stage introduction of the ─B(OH)2 moiety. THF-DMF, tetrahydrofuran-dimethylformamide. (C) Building block approach to prepare complex ─B(OH)2 moiety containing molecules in large numbers. Constantinos G. Neochoritis et al. Sci Adv 2019;5:eaaw4607 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).