Multiple Endocrine Neoplasia Type 2B and Hirschsprung’s Disease Raj P. Kapur  Clinical Gastroenterology and Hepatology  Volume 3, Issue 5, Pages 423-431 (May 2005) DOI: 10.1016/S1542-3565(04)00676-7 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Location and nature of RET mutations associated with MEN2A, MEN2B, and FMTC (A), as well as a subset of reported mutations associated with HSCR (B). SP, signal peptide; grey ovals, cysteine residues affected in MEN2A or FMTC; TK, tyrosine kinase domain; X, substituted amino acid; -, stop codon. Adapted from Chakravarti,17 Eng and Mulligan,4 and Yip et al.3 Clinical Gastroenterology and Hepatology 2005 3, 423-431DOI: (10.1016/S1542-3565(04)00676-7) Copyright © 2005 American Gastroenterological Association Terms and Conditions