Clinical and biologic evaluation of ovarian function in women treated by bone marrow transplantation for various indications during childhood or adolescence

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Presentation transcript:

Clinical and biologic evaluation of ovarian function in women treated by bone marrow transplantation for various indications during childhood or adolescence Pascale Jadoul, M.D., Ellen Anckaert, Ph.D., Ann Dewandeleer, M.D., Mélanie Steffens, M.Sc., Marie-Madeleine Dolmans, M.D., Ph.D., Christiane Vermylen, M.D., Ph.D., Johan Smitz, M.D., Ph.D., Jacques Donnez, M.D., Ph.D., Dominique Maiter, M.D., Ph.D. Fertility and Sterility Volume 96, Issue 1, Pages 126-133.e3 (July 2011) DOI: 10.1016/j.fertnstert.2011.03.108 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Antimüllerian hormone (AMH) concentrations (μg/L) according to administration or not of total body irradiation as conditioning treatment before bone marrow transplantation. Straight horizontal lines represent medians. Fertility and Sterility 2011 96, 126-133.e3DOI: (10.1016/j.fertnstert.2011.03.108) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 (A) Probability of persistent ovarian function after treatment with bone marrow transplantation (BMT) as a function of total body irradiation (TBI) or no TBI as conditioning treatment. The probability of having active ovarian function 5 years after treatment was 70% if no TBI had been given and only 21% if TBI had been administered (P=.002; Mantel-Cox log-rank test). (B) Probability of persistent ovarian function after treatment with BMT according to age at the time of treatment. The probability of having active ovarian function 5 years after treatment was 59% if age at BMT was ≤10 years and only 22% if age at BMT was >10 years (P=.007; Mantel-Cox log-rank test). Fertility and Sterility 2011 96, 126-133.e3DOI: (10.1016/j.fertnstert.2011.03.108) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Antimüllerian hormone (AMH) concentrations in patients with or without clinically proven persistent ovarian function (left) at any time and (right) at 10 years after bone marrow transplantation. Straight horizontal lines represent medians. Fertility and Sterility 2011 96, 126-133.e3DOI: (10.1016/j.fertnstert.2011.03.108) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions