Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:

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Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A: Scatterplot depicting tumor weights measured at study termination in mice receiving either metformin (250 mg/kg, n = 14), rapamycin (2.5 mg/kg, n = 14), or vehicle (0.1% DMSO in saline, n = 11). B and C: Representative images of pancreatic tumors analyzed by immunohistochemical staining of pAkt, pmTOR, and pACC. C: Quantification of pAkt, pmTOR, and pACC positively stained cells in tumor tissues. Original magnification ×40. Scale bar represents 100 nm. Data are expressed as mean ± SEM number of positive cells per field in tumors (n = 8 per group). *P < 0.05 by one-way ANOVA. Vincenza Cifarelli et al. Diabetes 2015;64:1632-1642 ©2015 by American Diabetes Association