Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.

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Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose.

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Molecular Therapy - Methods & Clinical Development

Rashmi B. Prasad, Leif Groop Cell Metabolism

Insulin and glucagon secretion: nondiabetic and diabetic subjects.

Volume 125, Issue 4, Pages (October 2003)

Volume 10, Issue 3, Pages (March 2018)

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Presentation transcript:

Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose (G). Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose (G). Islets from Sst+/+ or Sst−/− mice were perifused in the presence of alanine, glutamine, and arginine (2 mmol/L each, mix AA). The G concentration was changed between 1 and 7 mmol/L as indicated. B: Glucagon secretion from the experiments illustrated in (A) is expressed as percentage of secretion during the last 12 min in G1. Traces are means ± SE for three (Sst+/+) or five (Sst−/−) experiments with islets from different preparations. Rui Cheng-Xue et al. Diabetes 2013;62:1612-1622 ©2013 by American Diabetes Association