Avoiding reperfusion injury after limb revascularization: Experimental observations and recommendations for clinical application Friedhelm Beyersdorf,

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Presentation transcript:

Avoiding reperfusion injury after limb revascularization: Experimental observations and recommendations for clinical application Friedhelm Beyersdorf, MD a, Georg Matheis, MD a, Stefan Krüger, MD a, Anke Hanselmann, MD a, Hans-Georg Freisleben, PhD b, Guido Zimmer, MD b, Peter Satter, MD a Journal of Vascular Surgery Volume 9, Issue 6, Pages 757-766 (June 1989) DOI: 10.1016/0741-5214(89)90081-5 Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Water content of the soleus muscle after 4 hours of complete ischemia at 18° C and uncontrolled reperfusion (left bar) or controlled reperfusion (right bar). Note marked increase in tissue water content after reperfusion with a standard reperfusate at 100 mm Hg and normal tissue water content after control of the initial reperfusion for 30 minutes by lowering the perfusion pressure to 50 mm Hg and modifying the reperfusate. Values are mean ± standard deviation. Journal of Vascular Surgery 1989 9, 757-766DOI: (10.1016/0741-5214(89)90081-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Recovery of immediate contractions after electrical stimulation, shown as a percent of control contraction, after 4 hours of total ischemia at 18° C and uncontrolled reperfusion (left bar) or controlled reperfusion (right bar). Steady recovery occurred only when the conditions of reperfusion and the composition of the reperfusate are controlled. Values are mean ± standard deviation. Journal of Vascular Surgery 1989 9, 757-766DOI: (10.1016/0741-5214(89)90081-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions