Ado loss alters cellular metabolism.

Slides:

Advertisements

Similar presentations

Cytotoxicity of MSP samples to normal and cancer cell lines.

Advertisements

Degradation of MSP samples in 37°C DPBS solution.

Basic design concept of human mimetic humanoid.

TPAD controller performance for three force components.

Three different types of transfer functions with a codomain of [0,1].

TPAD training protocol.

Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells. Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells.

Force-strain characteristics of Peano-HASEL actuators using hydrogel and aluminum electrodes. Force-strain characteristics of Peano-HASEL actuators using.

Self-sensing of actuator position.

Workspace comparison of Delta robots.

T2-weighted cross-sectional MR imaging of MSP swarms inside SD rats.

Protein sequence alignment of the NS3 helicase–encoding region of 63 flaviviruses demonstrates conservation of a KIR2DS2-binding peptide. Protein sequence.

Ex vivo testing of the soft robotic devices.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Distribution of the number of collisions and the average closest-neighbor distance as a function of communication range and delay. Distribution of the.

Power-free sterilization of culture plate.

The foldable robotic arm with seven modules assembled in series.

Comparison of repertoire distributions to baseline.

A novice user executing various subtasks from study 1.

Tukey boxplots overlaid on data points from objective and subjective measures, displaying results from study 1. Tukey boxplots overlaid on data points.

Tfr cells robustly secrete IL-10 after acute viral infection.

Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. Tfr cell–derived IL-10 is important for B cell differentiation and.

DC subset cooperation for activation of antiviral T cells.

Definition of the cellular source of IL-22.

Protein sequence alignment of the NS3 helicase–encoding region of 63 flaviviruses demonstrates conservation of a KIR2DS2-binding peptide. Protein sequence.

BAP1 deficiency results in thymic atrophy and loss of thymocyte populations. BAP1 deficiency results in thymic atrophy and loss of thymocyte populations.

Quasi-static and dynamic trajectories.

Online verification using reachable occupancies.

Crystal structures of RSV G-antibody complexes.

Fig. 4 Restoration of MTAP expression produces heterogeneous effects on metabolism. Restoration of MTAP expression produces heterogeneous effects on metabolism.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 3 Responsiveness to alterations in other one-carbon nutrient availability is largely MTAP status independent. Responsiveness to alterations in other.

T2-weighted cross-sectional MR imaging of MSP swarms inside SD rats.

Experimental results for tremor reduction.

SoFi system overview. SoFi system overview. (Top, left to right) Soft robotic fish and diver interface module. (Bottom, left to right) Subcomponents of.

A summary of different energy sources for robotics.

Inverse correlation of baseline differences between young and older participants. Inverse correlation of baseline differences between young and older participants.

Fig. 3 Oil, gas, and FP water variations with time.

Microrobots with different cell-carrying capacities under different grid lengths (lg) and burr lengths (lb). Microrobots with different cell-carrying capacities.

Self-sensing of actuator position.

Fig. 1 Map of water stress and shale plays.

Brain-computer interfaces.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Experimental setup for workspace, bandwidth, and force characterization of the milliDelta. Experimental setup for workspace, bandwidth, and force characterization.

Immune evasion occurs through loss of TNF, IFN-γ, or antigen presentation pathways. Immune evasion occurs through loss of TNF, IFN-γ, or antigen presentation.

Active deformation of an RBC cargo propelled and pushed by a single bacterium through a 2-μm gap. Active deformation of an RBC cargo propelled and pushed.

Untethered kirigami-skinned soft crawlers.

Force-strain characteristics of Peano-HASEL actuators using hydrogel and aluminum electrodes. Force-strain characteristics of Peano-HASEL actuators using.

Degradation of MSP samples in 37°C DPBS solution.

NK cell immune evasion occurs through loss of TNF pathway members.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

T cell–derived cytokines drive immune evasion.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Underwater observatory.

Ado loss drives TNF-dependent immune evasion.

In vitro cell-release experiments on a glass substrate.

AEGIS autonomous targeting process.

Immune evasion occurs independently of perforin-mediated killing.

Fig. 2 Sampling. Sampling. (A) Extant stratigraphic section. Zenithal (B) and frontal (C) views of the flowstone capping the excavated deposit. The rectangle.

Discrimination accuracy across conditions.

Multiplexed four- and eight-channel devices for rapid processing

Bacterial antigen encounter occurs during a specific preweaning interval, is dependent on GCs, and correlates with the presence of colonic GAPs. Bacterial.

Breakdown of incorrect participant responses.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

ATP analogs have little effect on the conformation of the 2CARD domain

Cartoon model for the increased p-HLA display engendered by peptide splicing. Cartoon model for the increased p-HLA display engendered by peptide splicing.

Fig. 4 Effects of individual picosecond and microsecond pulses.

In response to allergen, T cells and ILCs are equally important sources of IL-13. In response to allergen, T cells and ILCs are equally important sources.

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Ado loss alters cellular metabolism. Ado loss alters cellular metabolism. Control or Ado knockout MC38 cells were subjected to amine derivatization/liquid chromatography–MS (cysteamine, cystamine, taurine, and glutathione) and GC-MS polar metabolomics (cystamine, taurine, cysteine, and hypotaurine). ATP, adenosine 5′-triphosphate; ADP, adenosine 5′-diphosphate; AMP, adenosine 5′-monophosphate. *P < 0.01, **P < 0.001, ***P < 0.0001, ****P < 0.00001. NS, not significant. Conor J. Kearney et al. Sci. Immunol. 2018;3:eaar3451 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works