Fig. 6. Gross morphological inner ear defects in Tbx1;Jag1 compound mutant embryos at E15.5. Gross morphological inner ear defects in Tbx1;Jag1 compound.

Slides:

Advertisements

Similar presentations

DEVELOPMENT OF EAR By Dr Samina Anjum.

Advertisements

Figure The Anatomy of the Ear

© 2012 Pearson Education, Inc. Figure The Anatomy of the Ear External Ear Elastic cartilages Auricle External acoustic meatus Tympanic membrane Tympanic.

Otic; Vestibular; Auditory

Figure 25.1 Anatomy of the ear.

Reena Shakya, Tomoko Watanabe, Frank Costantini Developmental Cell

An Iron-Rich Organelle in the Cuticular Plate of Avian Hair Cells

Ocular defects produced by Daam1 mutation and in combination with diabetes. Ocular defects produced by Daam1 mutation and in combination with diabetes.

Hmx2 and Hmx3 Homeobox Genes Direct Development of the Murine Inner Ear and Hypothalamus and Can Be Functionally Replaced by Drosophila Hmx Weidong Wang,

Hmx2 and Hmx3 Homeobox Genes Direct Development of the Murine Inner Ear and Hypothalamus and Can Be Functionally Replaced by Drosophila Hmx Weidong Wang,

Volume 10, Issue 21, Pages (November 2000)

Volume 16, Issue 12, Pages (June 2006)

Volume 4, Issue 6, Pages (December 2001)

DEVELOPMENT OF EAR Dr Samina Anjum.

An Iron-Rich Organelle in the Cuticular Plate of Avian Hair Cells

Muscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function Sudipto Roy, L.S. Shashidhara, K VijayRaghavan

Volume 19, Issue 16, Pages (August 2009)

Volume 22, Issue 2, Pages (February 2012)

Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency

Sonic hedgehog and vascular endothelial growth factor Act Upstream of the Notch Pathway during Arterial Endothelial Differentiation Nathan D. Lawson,

Bmp2 Signaling Regulates the Hepatic versus Pancreatic Fate Decision

Drosophila atonal Fully Rescues the Phenotype of Math1 Null Mice

Won-Suk Chung, Didier Y.R. Stainier Developmental Cell

Distinct mechanisms regulate slow-muscle development

Percentage fractions of (β-Gal+) PCs in 32-week-old heterozygous females differ between cerebellar lobules affected and spared from degeneration of Purkinje.

Autonomous Modes of Behavior in Primordial Germ Cell Migration

Fig. 6. crb_C mutant photoreceptor cells exhibit normal morphology.

Islet Coordinately Regulates Motor Axon Guidance and Dendrite Targeting through the Frazzled/DCC Receptor Celine Santiago, Greg J. Bashaw Cell Reports

Fig. 1. Overview of the nervous system of the adult S. roscoffensis.

Fig. 3. Hts and Dlg are in a complex at the postsynaptic membrane of larval NMJs.(A–B″) PLA with HtsM and Dlg antibodies (green) performed on third instar.

Fig. 1. Bj mutant exhibits outflow tract malalignment defects.

Fig. 6. Cross-section of the stomach wall and spiral intestine of the embryo, stained with PAS. (A) Surface of the stomach wall (SW) and ingested material.

Embryonic corneal defects in E18.5 AP-2β NCC KO mutant embryos.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Fig. 1. Loss of PC following INT depletion

Scanning EM shows cilia abnormalities in the neural tube.

Fig. 1. γ-Tubulin localizes in close proximity to centriole walls in interphase but within an extended PCM meshwork in mitosis.U2OS cells were fixed and.

Fig. 4. Non-autonomous rescue of puc expression in DME cells

Fig. 2. The kar phenotype arises during metamorphosis

Fig. 2. Blocking of BMP signaling, but not of nodal signaling, inhibits autochthonous neural crest migration in zebrafish embryos. Blocking of BMP signaling,

Fig. 7. Representative images of control (Cas9+GFP) and Cas9+gRNA+GFP co-injected embryos on day 4 of culture, showing nuclear-imported GFP (green) and.

Delayed formation of sensory hair cells in dlx3b/4b-deficient embryos

Simultaneous perturbations to shuttling result in defects in the Dl gradient and in the sna domain. Simultaneous perturbations to shuttling result in defects.

The sh339 and qmc554 alleles of gfi1b.

Schematic of the events during early otic development in zebrafish

The idefix phenotype first becomes visible during metamorphosis

Fig. 8. The morphology of the ventral nerve cord in Ror-Myc overexpressing embryos is normal. The morphology of the ventral nerve cord in Ror-Myc overexpressing.

The feelgood mutation affects craniofacial skeletal development.

Reb does not play a significant role in regulating TGF-β signaling

Fig. 1. Embryonic development of T. toreumaticus.

Fig. 1. Loss of PC following INT depletion

Depleting CK2 restores centrosomal ZYG-1 levels in zyg-1(it25) embryos

Folic acid increases apical junctional pMLCK localization in vivo

Male and female Tg(fli1a:EGFP) blood vessel regeneration.

Fig. 2. Tbx1 lineage is largely complementary to the NSD

Fig. 4. Inactivation of Tbx1 and Jag1 with Tbx1Cre results in expanded proneural gene expression. Inactivation of Tbx1 and Jag1 with Tbx1Cre results in.

Tagln-Cre:Tgfbr2flx/flx embryos develop VBW closure defects.

Fig. 3. MO-mediated smc3 knockdown results in reduced regenerate length, segment length and cell proliferation. MO-mediated smc3 knockdown results in reduced.

Fig. 1. Expression of a Ror-eGFP fusion protein under control of the endogenous Ror promoter in Drosophila embryos. Expression of a Ror-eGFP fusion protein.

Fig. 6. Bj mutants show stereocilia patterning defects and biliary duct (BD) malformations. Bj mutants show stereocilia patterning defects and biliary.

Fig. 2. Defective development of lymphatic vessels in zebrafish embryos treated with cigarette smoke extract or snuff extract. Defective development of.

Adult Acvr1;Trp53DCKO lenses form vascularized, tumor-like structures at their posterior poles. 4-month-old Trp53CKO and Acvr1;Trp53DCKO lenses were sectioned.

A Bmp/Admp Regulatory Circuit Controls Maintenance and Regeneration of Dorsal- Ventral Polarity in Planarians Michael A. Gaviño, Peter W. Reddien Current.

Fig. 1. Lhx1 is expressed in the proximal region of the OV

Integrins modulate the Notch pathway by regulating its intracellular trafficking and/or processing. Integrins modulate the Notch pathway by regulating.

Phenotypic analysis of the CNS in mutants for Ror, otk and otk2

Lysosomal duplication and segregation defects after TbCALM depletion.

Dynamic and polarized recruitment of ERC1a near protrusive sites during migration. Dynamic and polarized recruitment of ERC1a near protrusive sites during.

Co-expression of periostin and Sox10 in DRG and DRG explant cultures.

Nuclear invaginations observed in thin sections are 3D tunnels and crevices, as shown by FIB-SEM and STORM. (A) In thin section TEM, large nuclear invaginations.

Presentation transcript:

Fig. 6. Gross morphological inner ear defects in Tbx1;Jag1 compound mutant embryos at E15.5. Gross morphological inner ear defects in Tbx1;Jag1 compound mutant embryos at E15.5. (A) Paintfilling of E15.5, Tbx1Cre/+;Jag1flox/+, Tbx1Cre/+;Jag1flox/flox, Tbx1Cre/−, Tbx1Cre/−;Jag1flox/+ and wild-type control inner ears. Tbx1Cre/+;Jagflox/+ ears are relatively normal but present with narrowing of the canals, particularly the anterior canal (white asterisk). Tbx1Cre/+;Jagflox/flox ears display incomplete development of the anterior semicircular canal (ac), posterior semicircular canal (pc) and lateral semicircular canal (lc), as well as their associated ampullae, respectively (aa, pa, la) (white asterisks). Tbx1Cre/− mutant ears have an enlarged endolymphatic duct (ed) (white tracing), while the rest of the inner ear does not fully develop and remains a vesicle with a posterior protrusion. Tbx1Cre/−;Jagflox/+ mutant ears are similar to Tbx1Cre/− ears but the vesicle is smaller and the protrusion is extended ventrally. (B) Transverse histological sections stained by H&E. All three cristae develop normally in Tbx1Cre/+;Jag1flox/+ embryos (a,b). The anterior crista (ac) and lateral crista (lc) attached to the utricle (u) are shown. An image of b at a higher magnification in the inset shows rows of hair cells (hc) and support cells (sc) that develop normally. All three cristae are missing from Tbx1Cre/+;Jag1flox/flox ears (a′,b′). Vestibular (vg) and spiral ganglia (sg) appear to form normally in Tbx1Cre/+;Jag1flox/+ embryos (c,d). The vg is noticeably smaller in Tbx1Cre/+;Jag1flox/flox embryos while the sg appears to develop normally (c′,d′). The inner ear rudiment (the vesicle ventral of the endolymphatic duct) in Tbx1Cre/− mutants overall are mostly lacking in hair cells, particularly in lateral regions (red arrowhead); however, the medial ventral wall of the vesicle is fairly densely populated with hair cells (black arrowhead) (e). An image of e at a higher magnification is shown in f. Tbx1Cre/−;Jag1flox/+ ears are similar to Tbx1Cre/− ears in that they are mostly lacking hair cells, particularly in lateral regions (red arrowhead) (e′). Medial regions are populated by some hair cells, but much more sparsely. An image of e′ at a higher magnification is shown in f′. Stephania Macchiarulo, and Bernice E. Morrow Biology Open 2017;6:1472-1482 © 2017. Published by The Company of Biologists Ltd