Time course of AMPA receptors after blocking exocytosis/endocytosis.

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Time course of AMPA receptors after blocking exocytosis/endocytosis. Time course of AMPA receptors after blocking exocytosis/endocytosis. A, Blocking exocytosis. With receptors at basal steady state at time t < 0, exocytosis is blocked by setting σj = 0 (j = 1,2) at t = 0. The number of AMPA receptors in the PSD almost halves in <10 min (because of the loss of free receptors) and decreases to ∼1 over ∼10 d (data not shown). B, Blocking endocytosis. Endocytosis is blocked by setting kj = 0 (j = 1,2) at t = 0. The number of AMPA receptors in the PSD nearly doubles within 1 h (because of the addition of free receptors) and reaches a new steady-state value of ∼84. These results are consistent with those of Luscher et al. (1999). Berton A. Earnshaw, and Paul C. Bressloff J. Neurosci. 2006;26:12362-12373 ©2006 by Society for Neuroscience