Repressing the Keratinocyte Genome: How the Polycomb Complex Subunits Operate in Concert to Control Skin and Hair Follicle Development  Vladimir A. Botchkarev, Andrei N. Mardaryev  Journal of Investigative Dermatology  Volume 136, Issue 8, Pages 1538-1540 (August 2016) DOI: 10.1016/j.jid.2016.04.026 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Polycomb group genes and the control of skin development. Polycomb group proteins form two major complexes, PRC1 (a) and PRC2 (b). Both complexes contain core subunits that interact with other accessory proteins and define the complete composition of each subcomplex. The accessory proteins regulate recruitment to specific chromatin domains and/or modulate the catalytic activity of the core complex. (a) Association of PRC1 core subunits Ring1a/b and Pcgf2/4 with one of Phc and Cbx proteins defines the canonical PRC1 complex, while a complex with RING/YY1 binding protein (RYBP)/YAF and/or KDM2B forms the noncanonical PRC1. (b) Three core subunits of PRC2 can associate with different proteins at the same time. (c) Summary of the effects of the ablation of the distinct Polycomb group genes on skin development (Bardot et al., 2013; Ezhkova et al., 2009, 2011; Luis et al., 2011; Mardaryev et al., 2016). KDM2B, lysine-specific demethylase 2B; YAF, YY1 associated factor. Journal of Investigative Dermatology 2016 136, 1538-1540DOI: (10.1016/j.jid.2016.04.026) Copyright © 2016 The Authors Terms and Conditions