PK-M2 Makes Cells Sweeter on HIF1

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PK-M2 Makes Cells Sweeter on HIF1 Daniel A. Tennant Cell Volume 145, Issue 5, Pages 647-649 (May 2011) DOI: 10.1016/j.cell.2011.05.009 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Differential Regulation of HIF1α and PK-M2 by PHDs As oxygen levels decrease, the transcription factor hypoxia-inducible factor 1 α (HIF1α) is stabilized and can strongly induce its target genes. Once levels are close to anoxia, pyruvate kinase M2 (PK-M2) hydroxylation is decreased, and HIF1 transactivation activity is weaker. FBP, fructose 1,6-bisphosphate; GLUT1, glucose transporter 1; HRE, hypoxia response element; LDHA, lactate dehydrogenase A; PEP, phosphoenol pyruvate; PDK1, pyruvate dehydrogenase kinase 1; PK-M2, pyruvate kinase M2; PHD, prolyl hydroxylase domain; Ub, ubiquitin; pVHL, von Hippel Lindau protein. Cell 2011 145, 647-649DOI: (10.1016/j.cell.2011.05.009) Copyright © 2011 Elsevier Inc. Terms and Conditions