Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways Gert-Jan Braunstahl, MDa, b, Shelley.

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Presentation transcript:

Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways Gert-Jan Braunstahl, MDa, b, Shelley E. Overbeek, MD, PhDb, Alex KleinJan, BSca, Jan-Bas Prins, PhDb, Henk C. Hoogsteden, MD, PhDb, Wytske J. Fokkens, MD, PhDa Journal of Allergy and Clinical Immunology Volume 107, Issue 3, Pages 469-476 (March 2001) DOI: 10.1067/mai.2001.113046 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Study design. Bronchial and nasal biopsy specimens, as well as blood samples, were collected from patients and control subjects before (T0) and 24 hours (T24) after NP. Symptom scores (VAS), PNIF, and PEF were recorded at the beginning of each visit (T0 and T24), one half hour after NP and bronchoscopy (T1/2 and T241/2), and at 2-hour intervals after NP (T2-T12). Journal of Allergy and Clinical Immunology 2001 107, 469-476DOI: (10.1067/mai.2001.113046) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Symptoms were individually expressed in millimeters on a 10-cm VAS, and a composite score was obtained for nasal complaints (A, rhinorrhea, watery eyes, nasal itching, sneezing, and nasal blockage) and pulmonary complaints (C, wheezing, coughing, shortness of breath, and decreased exercise intolerance). PNIF (B) and PEF (D) were expressed in liters per minute. Baseline values were taken to be 0. Consecutive measurements were plotted as the difference from baseline (mean ± SEM). *P < .05 (Mann-Whitney U test). Journal of Allergy and Clinical Immunology 2001 107, 469-476DOI: (10.1067/mai.2001.113046) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Nasal mucosal sections taken from patients with AR before and 24 hours after nasal provocation. Immunohistochemical staining for ICAM-1 (A and E ), VCAM-1 (B and F ), E-selectin (C and G ), and CD31 (D and H ). Counterstained with hematoxylin (original magnification, 100×). Journal of Allergy and Clinical Immunology 2001 107, 469-476DOI: (10.1067/mai.2001.113046) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 4 Bronchial mucosal sections taken from patients with AR before and 24 hours after NP. Immunohistochemical staining for ICAM-1 (A and E ), VCAM-1 (B and F ), E-selectin (C and G ), and CD31 (D and H ). Counterstained with hematoxylin (original magnification, 100×). Journal of Allergy and Clinical Immunology 2001 107, 469-476DOI: (10.1067/mai.2001.113046) Copyright © 2001 Mosby, Inc. Terms and Conditions