Neoadjuvant and Adjuvant Chemotherapy in Resected Pulmonary Large Cell Neuroendocrine Carcinomas: A Single Institution Experience Inderpal S. Sarkaria,

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Neoadjuvant and Adjuvant Chemotherapy in Resected Pulmonary Large Cell Neuroendocrine Carcinomas: A Single Institution Experience Inderpal S. Sarkaria, MD, Akira Iyoda, MD, Mee Soo Roh, MD, Gabriel Sica, MD, PhD, Deborah Kuk, MS, Camelia S. Sima, MD, Maria C. Pietanza, MD, Bernard J. Park, MD, William D. Travis, MD, Valerie W. Rusch, MD The Annals of Thoracic Surgery Volume 92, Issue 4, Pages 1180-1187 (October 2011) DOI: 10.1016/j.athoracsur.2011.05.027 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Advanced stage III/IV is associated with decreased overall survival in patients with resected large cell neuroendocrine carcinoma. (— = I; ··· = II; ·–· = III/IV.) The Annals of Thoracic Surgery 2011 92, 1180-1187DOI: (10.1016/j.athoracsur.2011.05.027) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Tumor T stage is associated with decreased overall survival in patients with resected large cell neuroendocrine carcinoma. (— = T1; ··· = T2; ·–· = T3/T4.) The Annals of Thoracic Surgery 2011 92, 1180-1187DOI: (10.1016/j.athoracsur.2011.05.027) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Tumor N stage is associated with decreased overall survival in patients with resected large cell neuroendocrine carcinoma. (— = 0; ··· = 1; ·–· = 2/3.) The Annals of Thoracic Surgery 2011 92, 1180-1187DOI: (10.1016/j.athoracsur.2011.05.027) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Male gender is associated with decreased overall survival in patients with resected large cell neuroendocrine carcinoma. (— = female; — = male.) The Annals of Thoracic Surgery 2011 92, 1180-1187DOI: (10.1016/j.athoracsur.2011.05.027) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Stage IB large cell neuroendocrine carcinoma is associated with decreased overall survival compared with stage IA. (— = IA; ··· = IB.) The Annals of Thoracic Surgery 2011 92, 1180-1187DOI: (10.1016/j.athoracsur.2011.05.027) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Trend toward improved survival in patients with advanced stage IB–IIIA completely resected (R0) large cell neuroendocrine carcinomas treated with induction and (or) adjuvant platinum-based combination chemotherapy. (— = no; ··· = yes.) The Annals of Thoracic Surgery 2011 92, 1180-1187DOI: (10.1016/j.athoracsur.2011.05.027) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions