A critique of the Women’s Health Initiative hormone therapy study

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Presentation transcript:

A critique of the Women’s Health Initiative hormone therapy study Edward L. Klaiber, M.D., William Vogel, Ph.D., Susan Rako, M.D. Fertility and Sterility Volume 84, Issue 6, Pages 1589-1601 (December 2005) DOI: 10.1016/j.fertnstert.2005.08.010 Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Number of deaths in women due to heart disease and cerebrovascular disease in the year 2000. Klaiber. A critique of the Women’s Health Initiative. Fertil Steril 2005. Fertility and Sterility 2005 84, 1589-1601DOI: (10.1016/j.fertnstert.2005.08.010) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Comparing serum E2 levels in menopausal women with differing duration of menopause (short vs. long) on placebo (Pl), followed by 1.5 mg of estropipate (E) for 28 days, and 1.5 mg of estropipate plus 1.0 mg of norethindrone (P) added during the last 10 days of estropipate administration. Short duration of menopause (average 12.9 months); agea = 50.7 ± 2.7 years. Long duration of menopause (average 76.6 months); ageb = 55.3 ± 5.3 years. a vs. b P<.005. Klaiber. A critique of the Women’s Health Initiative. Fertil Steril 2005. Fertility and Sterility 2005 84, 1589-1601DOI: (10.1016/j.fertnstert.2005.08.010) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions