Anti-hOX40L treatment prevents aGVHD development in NOG mice transplanted with human PBMCs. NOG mice received human PBMCs (1 × 107) via tail vein. animals.

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Anti-hOX40L treatment prevents aGVHD development in NOG mice transplanted with human PBMCs. NOG mice received human PBMCs (1 × 107) via tail vein. animals were given anti-hOX40L or IgG2b (10 μg per dose) i.p. three times weekly from day 1 posttransplantation through week 3. Anti-hOX40L treatment prevents aGVHD development in NOG mice transplanted with human PBMCs. NOG mice received human PBMCs (1 × 107) via tail vein. animals were given anti-hOX40L or IgG2b (10 μg per dose) i.p. three times weekly from day 1 posttransplantation through week 3. (A) Body weight changes, (B) survival rates, (C) GVHD scores, (D) frequency of circulating human CD45+ leukocytes, (E) frequency of CD3+ T cells in whole blood, and (F) frequency of human CD3+ T cells in human CD45+ cells. Error bars represent mean ± SD (n = 5 mice per group). Data are representative of three independent experiments. The p values were determined with unpaired Student t test in (A) and (C)–(F) and Mantel–Cox log-rank test in (B). *p < 0.05, **p < 0.01, ***p < 0.005. Trivendra Tripathi et al. ImmunoHorizons 2019;3:110-120 Copyright © 2019 The Authors