A-N: Immunofluorescence analysis of Bcl family genes in human islets of Langerhans. A-N: Immunofluorescence analysis of Bcl family genes in human islets.

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A-N: Immunofluorescence analysis of Bcl family genes in human islets of Langerhans. A-N: Immunofluorescence analysis of Bcl family genes in human islets of Langerhans. Human pancreatic sections were stained with the following antibodies: anti-Bid (A); anti-Bad (E); anti-Bik (G); anti–Bcl-xl (L); anti-insulin (B and D); antiglucagon (H); and antichromogranin (M). Note the expression of proteins in the cytoplasmic compartment of cells. Merged confocal sections showed almost complete colocalization of Bid and Bad with insulin (C and F, respectively), a partial colocalization of Bik with glucagon (I), and a partial colocalization of Bcl-xl with chromogranin (N) (original magnification 330×). Massimo Federici et al. Diabetes 2001;50:1290-1301 ©2001 by American Diabetes Association