Suggested treatment algorithm for resistant lupus nephritis Suggested treatment algorithm for resistant lupus nephritis.Resistant indicates 25% decline in estimated GFR or ESRD, 100% increase in urinary protein/urinary creatinine ratio, or the presence of an active urinary sediment. Suggested treatment algorithm for resistant lupus nephritis.Resistant indicates 25% decline in estimated GFR or ESRD, 100% increase in urinary protein/urinary creatinine ratio, or the presence of an active urinary sediment. LN, lupus nephritis; MMF, mycophenolate mofetil; NIH, National Institutes of Health; ELNT, Euro-Lupus Nephritis Trial; CYC, cyclophosphamide; CNI, calcineurin inhibitor. Sean Kalloo et al. CJASN 2013;8:154-161 ©2013 by American Society of Nephrology