Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib Pär Gyllfors,

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Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib Pär Gyllfors, MDa, Grazyna Bochenek, MDb, John Overholt, MDc, Diane Drupka, BScd, Maria Kumlin, BM, PhDe, James Sheller, MD, PhDc, Ewa Nizankowska, MD, PhDb, Peter C. Isakson, PhDd, Filip Mejza, MDb, James B. Lefkowith, MDd, Sven-Erik Dahlén, MD, PhDe, Andrew Szczeklik, MD, PhDb, John J. Murray, MD, PhDc, Barbro Dahlén, MD, PhDf Journal of Allergy and Clinical Immunology Volume 111, Issue 5, Pages 1116-1121 (May 2003) DOI: 10.1067/mai.2003.1450 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Urinary excretion of LTE4 (mean ± SD) before and after positive screening challenge with aspirin in 19 of the subjects participating in the study. The postchallenge value represents the peak excretion within 2 hours after the final dose of aspirin. The postchallenge (Post) value is highly significantly different from the prechallenge (Pre) value (P < .001, Student paired t test). Journal of Allergy and Clinical Immunology 2003 111, 1116-1121DOI: (10.1067/mai.2003.1450) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 A, Pulmonary function measured as FEV1 in liters (n = 33, mean ± SD) during the cross-over, double-blind, increasing-dose challenge with celecoxib and placebo. Four subjects who were sensitive to very low doses of aspirin entered this protocol after having been subjected to placebo and 5 mg of celecoxib at -2 hours without any reactions. B, Pulmonary function measured as FEV1 in liters (n = 33, mean ± SD) during the open-label challenge with 200-mg celecoxib suspension followed by a 200-mg capsule. Journal of Allergy and Clinical Immunology 2003 111, 1116-1121DOI: (10.1067/mai.2003.1450) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Nasal symptom scores (n = 33, mean ± SD) during the double-blind and open-label challenge sessions. Journal of Allergy and Clinical Immunology 2003 111, 1116-1121DOI: (10.1067/mai.2003.1450) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 A, Urinary excretion of LTE4 during the double-blind sessions (n = 33, mean ± SD). The value at any time point after the start of the challenges was not statistically different from baseline (time = 0). B, Urinary excretion of LTE4 during the open-label celecoxib challenge session (n = 33, mean ± SD). The value at any time point after the start of the challenges was not statistically different from baseline (time = 0). Journal of Allergy and Clinical Immunology 2003 111, 1116-1121DOI: (10.1067/mai.2003.1450) Copyright © 2003 Mosby, Inc. Terms and Conditions