High maternal expression of Cnot6l, an active component of the CCR4–NOT deadenylase complex. High maternal expression of Cnot6l, an active component of.

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High maternal expression of Cnot6l, an active component of the CCR4–NOT deadenylase complex. High maternal expression of Cnot6l, an active component of the CCR4–NOT deadenylase complex. (A) Schematic depiction of the mammalian CCR4–NOT deadenylase complex. The organization of the complex was compiled from the literature (9, 10, 41). Each CCR4–NOT complex contains two active deadenylase proteins, which can make four possible combinations: CNOT7+CNOT6, CNOT7+CNOT6L, CNOT8+CNOT6, and CNOT8+CNOT6L. CNOT6, CNOT6L, CNOT7, and CNOT8 are color-coded for easier navigation in the other panels. (B)Cnot6l transcript is highly enriched in the oocyte relative to somatic cells, whereas its alternating paralog Cnot6 is relatively depleted. The graph shows an expression ratio of CCR4–NOT complex components in oocytes and blastocysts relative to median expression values in somatic tissues calculated from the BioGPS GNF1M.gcrma tissue expression dataset (18) where expression in 61 mouse tissues was set to one. Expression of Cnot genes in somatic tissues (C), during OET in mice, cattle, and humans (D), and in hamster oocytes (E). Heatmaps and the graph show fragments per kilobase per million (FPKMs). Expression data from 22 tissues were selected from the ENCODE polyA RNA-seq mouse tissue panel (GSE49417) (42), and expression analysis of Cnot genes in oocytes and early embryos is based on published datasets from indicated species (19, 20, 21, 22, 35). Filip Horvat et al. LSA 2018;1:e201800084 © 2018 Horvat et al.