Treatment of G. mellonella-infected larvae with norfloxacin or norfloxacin plus TPGS in combination with the wild type or ΔbcnA mutant. Treatment of G.

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Treatment of G. mellonella-infected larvae with norfloxacin or norfloxacin plus TPGS in combination with the wild type or ΔbcnA mutant. Treatment of G. mellonella-infected larvae with norfloxacin or norfloxacin plus TPGS in combination with the wild type or ΔbcnA mutant. Larvae were infected with 100 CFU of bacteria for 24 h and then treated with the MIC of norfloxacin appropriate to each bacterial strain with or without 1.7 mM TPGS. Percent survival and the bacterial load (CFU/ml) in the larva’s hemolymph were determined at 48 h postinfection. The results represent the mean and SEM for 3 biological repeats. (A and B) Percent survival and bacterial load, respectively, of larvae infected with the parental K56-2 strain. (C and D) Percent survival and bacterial load, respectively, of ΔbcnA strain-infected larvae. Marwa M. Naguib, and Miguel A. Valvano mSphere 2018; doi:10.1128/mSphere.00564-18