Volume 77, Issue 12, Pages (June 2010)

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Volume 77, Issue 12, Pages 1098-1106 (June 2010) Atrial fibrillation in hemodialysis patients: clinical features and associations with anticoagulant therapy Volker Wizemann, Lin Tong, Sudtida Satayathum, Alex Disney, Takashi Akiba, Rachel B. Fissell, Peter G. Kerr, Eric W. Young, Bruce M. Robinson Kidney International Volume 77, Issue 12, Pages 1098-1106 (June 2010) DOI: 10.1038/ki.2009.477 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Prevalence of history of atrial fibrillation (AF) at DOPPS enrollment by region and age in prevalent cross-sections combining DOPPS I (1996–2001) and DOPPS II (2002–2004) (n=17,513). For comparison, the approximate prevalence of AF in the same age categories among 1.89 million adults in the US general population in 1996–1997 is also shown (ref. 5). Kidney International 2010 77, 1098-1106DOI: (10.1038/ki.2009.477) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 2 Hazard ratio (HR) for stroke according to warfarin use, by age categories among patients with a diagnosis of atrial fibrillation at DOPPS enrollment. The numbers of patients (strokes) were 1001 (35), 1137 (61), and 1107 (49) for age groups ≤65, 66 to 75, and >75 years, respectively. The numbers (%) of patients on warfarin were 146 (15%), 192 (17%), and 171 (15%) for age groups ≤65, 66 to 75, and >75 years, respectively. Patients with prosthetic heart valves (N=177) were excluded. Separate Cox models for each age category were used to estimate the hazard ratio and 95% confidence interval (whiskers) of first stroke after study entry, adjusted for age within the restricted category, sex, black race, years with ESRD, study phase, history of stroke, comorbid conditions as listed in Table 2, permanent pacemaker implanted, previous history of cardiac arrest, left ventricular hypertrophy, and valvular heart disease, stratified by region and study phase and accounting for effects of facility clustering. In addition to warfarin use, the following variables were statistically significant (P<0.05) in a model including all age categories: neurologic disease (P=0.02), diabetes (P=0.03), and previous history of stroke (P=0.002). Kidney International 2010 77, 1098-1106DOI: (10.1038/ki.2009.477) Copyright © 2010 International Society of Nephrology Terms and Conditions