Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps Joke Patou, MD, Philippe Gevaert, MD, PhD, Thibaut.

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Presentation transcript:

Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps Joke Patou, MD, Philippe Gevaert, MD, PhD, Thibaut Van Zele, MD, Gabriele Holtappels, Paul van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 1, Pages 110-115 (January 2008) DOI: 10.1016/j.jaci.2007.08.059 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Effect of 24 hours SEB (0.5 μg/mL) stimulation compared with RPMI on IFN-γ, IL-13, IL-5, IL-4, IL-2, TNF-α, IL-1β, IL-10, IL-8, IL-12p70, and TGF-β1 release. Comparison between nasal polyps (NP; n = 12) and inferior turbinates (IT; n = 13). ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology 2008 121, 110-115DOI: (10.1016/j.jaci.2007.08.059) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Effect of 30-minute stimulation with RPMI (baseline), SEB (0.5 μg/mL), SpA (10 μg/mL), and LTA (10 μg/mL) on histamine, LTC4/D4/E4, and PGD2 release in nasal polyps (NP; n = 8) and inferior turbinates (IT; n = 8). B, Effect of 24-hour stimulation with RPMI (baseline), SEB (0.5 μg/mL), SpA (10 μg/mL), and LTA (10 μg/mL) on histamine, LTC4/D4/E4, and PGD2 release in nasal polyps (NP; n = 8) and inferior turbinates (IT; n = 8). ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology 2008 121, 110-115DOI: (10.1016/j.jaci.2007.08.059) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Effect of 24-hour stimulation with SpA (10 μg/mL) compared with RPMI on IL-13 and IL-5 in inferior turbinates (IT; n = 8) and nasal polyps (NP; n = 8). ∗∗P < .01; NS, not significant. Journal of Allergy and Clinical Immunology 2008 121, 110-115DOI: (10.1016/j.jaci.2007.08.059) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions