A high-sugar diet induces insulin resistance.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.

Remote Control of Insulin Secretion by Fat Cells in Drosophila

Obesity accompanied by increased triacylglyceride deposits in InsP3R mutants leads to starvation resistance. Obesity accompanied by increased triacylglyceride.

The Drosophila chemical screening platform and summarised screen results. The Drosophila chemical screening platform and summarised screen results. (A)

Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor by Renald Delanoue, Eleonora Meschi, Neha Agrawal, Alessandra.

Volume 23, Issue 4, Pages (April 2016)

Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth Naoki Okamoto,

Volume 22, Issue 6, Pages (February 2018)

Susumu Hirabayashi, Thomas J. Baranski, Ross L. Cagan Cell

Fig. 2. Circulating VEGF in GCA patients up-regulates microvascular endothelial Jagged1. Circulating VEGF in GCA patients up-regulates microvascular endothelial.

Overexpression of sra exacerbates Aβ42-induced phenotypes in Aβ42-expressing flies. Overexpression of sra exacerbates Aβ42-induced phenotypes in Aβ42-expressing.

Volume 17, Issue 6, Pages (December 2009)

Volume 25, Issue 20, Pages (October 2015)

RLE-1, an E3 Ubiquitin Ligase, Regulates C

Volume 8, Issue 6, Pages (September 2014)

Volume 17, Issue 1, Pages (September 2016)

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals

Volume 11, Issue 5, Pages (May 2010)

Inducible DM1 model displays increased autophagy.

VacA does not induce phosphorylation of Src in RPTPα constitutive-knockdown AZ-521 cells. VacA does not induce phosphorylation of Src in RPTPα constitutive-knockdown.

A Drosophila cell culture model to study VAP(P58S) aggregation.

OA and related amines modulate motility and length of schistosomula.

The effects of laminarin, PMA and zymosan on PKC phosphorylation.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Crotonate increases histone crotonylation in mouse kidney.

Fig. 5. Expression of either dFMRP or human FMRP does not induce eIF2α phosphorylation.(A) Analysis of eIF2α phosphorylation upon dFMRP expression. Expression.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Fig. 7. The sma gene is necessary for ampA mRNA accumulation and its loss phenocopies some ampA effects.(A) RT-PCR showing levels of ampA transcripts in.

P53 is responsible for the induction of apoptosis, developmental malformations and mortality of G1 and G2tert mutant zebrafish. p53 is responsible for.

Fitm RNAi-1 knockdown in Drosophila interferes with morphology of nociceptive multi-dendritic sensory neurons. Fitm RNAi-1 knockdown in Drosophila interferes.

Identification of Z-FA-FMK as a potent compound that increases SMN protein expression in HEK293 and patient fibroblast cells. Identification of Z-FA-FMK.

Combined treatment with LY and sunitinib rescued hypervascularization.

Elevated pAkt level in ptena−/−ptenb−/− mutants is suppressed by LY and to a lesser extent by sunitinib. Elevated pAkt level in ptena−/−ptenb−/−

Reversal of MOR lysosomal targeting by silencing enhanced Rab7 expression. Reversal of MOR lysosomal targeting by silencing enhanced Rab7 expression. A:

Performance of Drosophila on diet supplemented with B vitamins.

CTG repeats do not affect the levels of TBPH transcripts nor TBPH alternative splicing. CTG repeats do not affect the levels of TBPH transcripts nor TBPH.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

Fig. 1. TSA at 165 nM induces maximal acetylation of histone H3 and near-maximal acetylation of histone H4.Immunoblot analysis of acetylated histones H3.

GFP–Sec61b mRNA competes with t-ftz mRNA for the ribosome-binding sites on the ER. (A,B) COS7 cells were transfected with plasmid containing a test gene.

P3/QBP1 co-treatment suppressed expanded-CAG-RNA-induced RNA toxicity and expanded-polyQ-protein-induced protein toxicity in vivo. P3/QBP1 co-treatment.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Oral administration of CX-4945 suppresses Tau phosphorylation in DYRK1A-overexpressing mice. Oral administration of CX-4945 suppresses Tau phosphorylation.

Immunohistochemistry of human DLB brains.

The Smurf phenotype shows increased blue-dye leakage from the gut into the body cavity with dietary supplementation. The Smurf phenotype shows increased.

Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. Impact of low-level galactose exposure on acute and long-term.

Compensatory hyperinsulinemia maintains euglycemia in HFHC-fed guinea pigs but is lost with STZ treatment. Compensatory hyperinsulinemia maintains euglycemia.

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.

Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance.

Angiotensin-(1-7) activates the IGF-1/Akt signalling pathway during muscle disuse through the Mas receptor. Angiotensin-(1-7) activates the IGF-1/Akt signalling.

Wrch-1 binds to the regulatory p85 subunit of PI3K and is necessary for Akt activation. Wrch-1 binds to the regulatory p85 subunit of PI3K and is necessary.

Fig. 6. IIS affected the soma area of most neurons in pharate adults, but not in larvae.(A,B) Pan-peptidergic expression pattern of 386-Gal4,UAS-CD8::GFP.

Loss of Graf results in plasmatocyte overproliferation.

Overexpression of cyp7a1 in the liver ameliorates tumor-induced liver inflammation. Overexpression of cyp7a1 in the liver ameliorates tumor-induced liver.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Peroxisome speeds were slower in patient and control cells.

Fig. 2. Acetylation stiffens primary cilia.

Running on the treadmill prolonged TrkB activation induced by exogenous BDNF in vivo. Running on the treadmill prolonged TrkB activation induced by exogenous.

Kinetics of BDNF-induced Erk, Akt and PLCγ activation in the presence of 15 mM NaCl or 15 mM KCl. Representative western blots (A) and quantitative plots.

Insulin resistance and hepatic steatosis in ASKO mice.

Cloning and expression of rat nesprin-1.

BCL-3 regulates expression of stemness-associated Wnt targets.

BMOL3 LPCs can differentiate towards the hepatocyte lineage.

Volume 18, Issue 9, Pages (May 2008)

Ubiquitin mediates the interaction between Smo and Vps36.

GOLPH3 interacts with COG complex proteins.

Oligomeric Aβ42 treatment induces expression of Ras and Cyclin D1 and activation of ERK in primary rat cortical neurons. Oligomeric Aβ42 treatment induces.

HDAC inhibitor induces RAG transcription in sensory neurons.

Time course of NMT knockdown.

Presentation transcript:

A high-sugar diet induces insulin resistance. A high-sugar diet induces insulin resistance.Canton-S larvae were reared on control and high-calorie diets. (A) Wandering L3 weights; n≥15. (B) Developmental time course to pupariation on all four diets; n=3. (C) Mono- and disaccharide sugars similarly elicit developmental delay. Sugar concentrations were 0.15 M (low sugar) and 1.0 M (high sugar) for disaccharides sucrose and maltose, and 2.0 M (high sugar) for monosaccharides fructose and glucose; n=3. (D) Young adult brains harboring DILP2-GAL4>UAS-GFP are highlighted in a 3D reconstruction of confocal images; n>10 brains per condition. (E) Quantitative RT-PCR of DILPs in 2- to 4-day-old adult male heads after rearing on both diets. DILP2, DILP3 and DILP5 transcripts were measured using actin5c as a control. P=0.06 for DILP2, P=0.04 for DILP3 and P=0.05 for DILP5 between control and high sugar; n≥7. A two-tailed t-test was used to derive P-values. (F) Western blot of hemolymph DILP2-FLAG from control- and high (0.7 M)-sugar-reared DILP2-GAL4>UAS-DILP2-FLAG wandering L3 larvae. Equal amounts of hemolymph were loaded in each lane. Canton-S (CS) served as a negative control. (G) Quantitation of high-sugar and control D2-FLAG signal on n=4 western blots. (H) Dissected organs from L3 male larvae raised on control or high-sugar diets were treated with insulin (0.5 μM) or vehicle and visualized using antibodies against Drosophila PO4-Akt, pan-Akt or syntaxin. (I) Bands from five western blot experiments were quantified, and PO4-Akt was normalized to syntaxin as a loading control; n=5. A one-tailed t-test was used to derive P-values. All error bars are ± s.e.m. Laura Palanker Musselman et al. Dis. Model. Mech. 2011;4:842-849 © 2011. Published by The Company of Biologists Ltd