Sialylated IgG1 gp120-specific Abs are increased in neutralizers.

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Sialylated IgG1 gp120-specific Abs are increased in neutralizers.

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Sialylated IgG1 gp120-specific Abs are increased in neutralizers. Sialylated IgG1 gp120-specific Abs are increased in neutralizers. (A) The radar plot shows the relative differences in gp120-specific IgG1, IgG2, IgG3, and IgG4 Ab titers in sera from neutralizers (N; red; n = 26) or non-neutralizers (NN; blue; n = 12). (B) The dot plot shows the gp120-specific IgG1 Ab titer differences across the neutralizers and non-neutralizers. (C) The radar plot describes the relative distribution of gp120-specific IgG Ab glycan levels in sera from neutralizers (N; red) or non-neutralizers (NN; blue). (D) The dot plot illustrates the percentage of sialylated gp120-specific IgG Abs among the groups. (E) The PLS-DA, using all Fc profile data including gp120-specific Ab titers, glycan profiles, binding to FcRs and complement proteins, ADCP, ADCD, and ADCC, was used to separate the two groups. Each dot represents a neutralizer (red) or non-neutralizer (blue). (F) The bar graph shows the variable importance in projection (VIP) score rank for the minimal Ab features that were used in the PLS-DA to separate the groups. As few as 17 of the total features collected across the cohort were required to nearly completely separate out the neutralizers and non-neutralizers. The variables were ranked in their importance in driving separation in the model, with the largest bars representing the most important contributions and the smallest bars representing more minimal contributions. The direction and color of the bars indicate whether the feature was enriched in the neutralizers (red) or in the non-neutralizers (blue). A Mann-Whitney test was used for statistical analysis in (B) and (D). *P < 0.05 and ***P < 0.001. The horizontal bars in all panels indicate mean, and error bars in all panels represent SEM. Giuseppe Lofano et al. Sci. Immunol. 2018;3:eaat7796 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).