mRNA adenosine-to-inosine editing increases under DR.

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mRNA adenosine-to-inosine editing increases under DR. mRNA adenosine-to-inosine editing increases under DR. (A) Average number of RNA edits in total and translated fractions across diets. RNA editing under DR is globally increased in the total fraction yet diminished in the translated fraction as compared with well-fed controls. Error bars are SEM. *P < 0.05, Wilcoxon rank sum test, n = 4. (B) Overlap of editing sites present in at least three of four biological replicates in total and translated mRNA under AL or DR. (C) Percentage of editing sites within the dataset located in 3′ UTRs as annotated in UTRome and the CDS. (D) Relationship between the change in editing frequency and polysome association under DR. Genes with edits occurring in their 3′ UTR are blue, edits occurring in the CDS are black. Regression line for 3′ UTR edits is blue, and line for CDS edits is black. Spearman correlation coefficient and associated P-value for 3′ UTR edits and for CDS genes are given in blue and black, respectively. TO, total mRNA; TR, translated mRNA; FC, fold change. Jarod A Rollins et al. LSA 2019;2:e201800281 © 2019 Rollins et al.