Aptamer released caused by various drug classes.

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Aptamer released caused by various drug classes. Aptamer released caused by various drug classes. The aptamer release from the rGO surface caused by drugs at 40 µM, as determined by fluorescence values, was measured in SELEX buffer (A) and in SELEX buffer plus 10% serum (B). The azole-class drugs posaconazole (POS), isavuconazole (ISV), and itraconazole (ITRA) liberated the greatest amount of aptamer. Polyene drugs (amphotericin B [AmB]), the azole drugs voriconazole (Vori) and fluconazole (Flu), and the drug para-aminobenzoic acid (PABA) elicited small amounts of aptamer release. Gregory R. Wiedman et al. mSphere 2018; doi:10.1128/mSphere.00623-18