In vivo effects of glucocorticoids on IgE production

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Presentation transcript:

In vivo effects of glucocorticoids on IgE production Zieg, MD, Lack, MD, Harbeck, PhD, Gelfand, MD, Leung, MD, PhD Journal of Allergy and Clinical Immunology Volume 94, Issue 2, Pages 222-230 (August 1994) DOI: 10.1053/ai.1994.v94.a54936

FIG. 1 Effect of prednisone on serum IgE (A) and IgG (B) levels. Ten patients with asthma were given a course of 20 mg of prednisone two times a day for 7 days. Serum immunoglobulins were drawn before and after prednisone treatment. All patients showed a significant increase in serum IgE levels (p = 0.005) but no significant change in serum IgG levels (p = 0.4). Journal of Allergy and Clinical Immunology 1994 94, 222-230DOI: (10.1053/ai.1994.v94.a54936)

FIG. 2 Effect of prednisone on serum allergen-specific IgE levels. Allergen-specific IgE was measured in 10 patients with asthma. The polyclonal IgE responses of four representative patients to the different allergens tested are shown (p = 0.0002). Journal of Allergy and Clinical Immunology 1994 94, 222-230DOI: (10.1053/ai.1994.v94.a54936)

FIG. 3 Effect of prednisone on IFN-γ (A) and IL-4 (B) synthesis. PBMCs (1 × 106 cells/ml) from 10 patients with asthma were cultured before and after a course of prednisone in the presence of concanavalin A (10 μg/ml) for 48 hours, after which supernatants were analyzed for IFN-γ and IL-4 levels by ELISA. IFN-γ, but not IL-4 (p = 0.6), synthesis was decreased in all patients (p = 0.005). Journal of Allergy and Clinical Immunology 1994 94, 222-230DOI: (10.1053/ai.1994.v94.a54936)

FIG. 4 Effect of prednisone on the frequency of IFN-γ–(A) and IL-4–(B) producing PBMCs. Intracellular staining for cytokine production was performed on serum samples from six patients. After prednisone treatment, the frequency of PBMCs producing IFN-γ, but not IL-4 (p = 1.0), was decreased (p = 0.03). Journal of Allergy and Clinical Immunology 1994 94, 222-230DOI: (10.1053/ai.1994.v94.a54936)

FIG. 5 Effect of prednisone on frequency of IFN-γ on different lymphocyte subpopulations. Intracellular staining for IFN-γ production was performed on serum samples from six patients. After prednisone treatment, the frequency of CD3(+) (A) and CD3(–) (B) IFN-γ–producing cells was decreased (p = 0.03). Journal of Allergy and Clinical Immunology 1994 94, 222-230DOI: (10.1053/ai.1994.v94.a54936)

FIG. 6 Regression analysis comparing the change in FEV1 with the rise in serum IgE. Eight patients with asthma performed pulmonary function studies before and after a course of prednisone. Regression analysis was performed to determine whether the rise in serum IgE had an effect on the results of pulmonary function studies. There was a direct correlation between these two variables (r = 0.76, p = 0.03). Journal of Allergy and Clinical Immunology 1994 94, 222-230DOI: (10.1053/ai.1994.v94.a54936)