Defects in neuronal and glial process outgrowth

Slides:



Advertisements
Similar presentations
FMRP suppresses dendritic Arc protein levels.
Advertisements

Aberrant wound architecture and proliferation in Rev3l-deficient skin.
Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.
Density of dendritic spines on L2/3 pyramidal neurons is greater in visual cortex of germline PirB−/− mice than in PirB+/+ mice at P30. Density of dendritic.
Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex  E.S Anton, Jordan A Kreidberg,
Figure 2 Brain biopsy Brain biopsy (A) Double staining with anti-aquaporin-4 (AQP4) antibody (dark green) and Luxol fast blue (blue) is shown. Loss of.
Characterization of the Dopamine Defect in Primary Cultures of Dopaminergic Neurons from Hypoxanthine Phosphoribosyltransferase Knockout Mice  Doug W.
Volume 19, Issue 1, Pages (July 1997)
Peptidergic nociceptor markers are reduced in DRG from Nav-Tsc2 mice.
Axonal swelling and impairment of dendritic development in Purkinje cells from Pex14ΔC/ΔC BL/ICR mouse upon treatment with BDNF. Axonal swelling and impairment.
Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signaling  S. Kudo, H. Mizuta,
Figure 1 VGCC antibody uptake in cerebellar slice culture
Impaired TrkB signaling in the cerebellum of Pex14ΔC/ΔC BL/ICR mice.
Hsp27 expression rescues PC12 cells and SCG neurons from JNK-induced cell death and elicits neurite outgrowth. Hsp27 expression rescues PC12 cells and.
Marta Nieto, Carol Schuurmans, Olivier Britz, François Guillemot 
Neuronal ATM level is reduced in mouse models of AD
ILK knockdown decreases mTOR signaling in PKD kidneys.
Animal cohort used for recording visually evoked neuronal responses.
Volume 17, Issue 2, Pages (October 2016)
Up-regulation of BDNF induces the neurite outgrowth of SH-SY5Y cells.
Multiangle-TIRF imaging of EGF-activated clathrin-mediated endocytosis
Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.
MET activation increases the density of Syn-GFP/bassoon and Syn-GFP/PSD-95 clusters in neocortical neurons. MET activation increases the density of Syn-GFP/bassoon.
Defects in neuronal cell migration from the SVZ
MET/β-catenin complexes during synapse development.
Fragment N expression does not affect islet morphology and cellularity
Loss of Cav1 function does not disrupt formation of dual projecting CPN/FPN axonal projections at P8. Loss of Cav1 function does not disrupt formation.
The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.
Characterization of NEX-CRE mice and analysis of Itgb1 expression by flow cytometry. a–n , Z/EG reporter mice carrying a CRE-inducible GFP transgene were.
Activation of glial cells.
Integrin β3 is dispensable for RhoA activity and contractility.
Chd5-deficient NSCs generate excessive astrocytes at the expense of neurons. Chd5-deficient NSCs generate excessive astrocytes at the expense of neurons.
Establishment of OL1 cells.
Deletion of HtrA1 does not alter vascular or immune cell morphology or distribution in the young-adult mouse neocortex. Deletion of HtrA1 does not alter.
c-Fos in RFMes GABAergic neurons across groups.
Neuronal and glial expression of Nogo-A and synaptic localization of Nogo-A and NgR 1 in the motor cortex. Neuronal and glial expression of Nogo-A and.
Marta Nieto, Carol Schuurmans, Olivier Britz, François Guillemot 
Fluorescence staining of F-actin in cultured astrocytes isolated from wild-type, MMP-2 null, and MMP-9 null mice using Texas Red-conjugated phalloidin.
Β-Actin overexpression in hippocampal neurons with ZBP1 knockdown is sufficient for partial phenotype rescue. β-Actin overexpression in hippocampal neurons.
Co-expression of periostin and Sox10 in DRG and DRG explant cultures.
IKKβ protects adipocytes from HFD-induced cell death.
Knockdown of ZBP1 in hippocampal neurons decreases dendritic branching
Diaphanous is required presynaptically for normal synaptic growth.
PTZ-induced neuronal activity visualized by IEGs
Sox11 and Sox4 are dynamically expressed during corticogenesis in overlapping and discrete cellular populations. Sox11 and Sox4 are dynamically expressed.
Effects of the genotypes of Rapgef2 and Rapgef6 on the distribution of neural progenitor cells. Effects of the genotypes of Rapgef2 and Rapgef6 on the.
Expression of p130CAS in primary culture neurons
Identification of a novel subset of mDA neurons in the VTA that expresses Neurod6, OTX2, CALBINDIN1, ALDH1A1, and Grp. Identification of a novel subset.
Non-cell-autonomous changes in retrograde signaling lead to cell death
Topographic organization of CA3 to CA1 projections revealed through monosynaptic rabies tracing by specifically targeting CA1 pyramidal cells along the.
A, Mean neurite length (± SEM) per motoneuron in 48 hr cultures after treatment with different concentrations of thrombin (1–1000 nm). A, Mean neurite.
Proprioceptive sensory neurons and muscle spindles are marked reduced in adult Swl/+ mice. Proprioceptive sensory neurons and muscle spindles are marked.
Activity regulates eEF2K-dependent spine morphogenesis.
TOMA does not affect NFTs in posterior hypothalamus or cortex.
High titers of peripheral anti-Aβ antibodies do not reduce Aβ deposits in aged Tg-SwDI mice. High titers of peripheral anti-Aβ antibodies do not reduce.
Gene expression changes in the PFC of mice with decreased TrkB expression. Gene expression changes in the PFC of mice with decreased TrkB expression. A-I,
Interneurons originate outside the Emx1 lineage
Abnormal morphologies are prevented by overexpression of CaN inhibitory peptide AKAP79 in APP/PS1 mouse brain. Abnormal morphologies are prevented by overexpression.
Absence of PC-induced ischemic tolerance in P2X7−/− mice.
Coexpression of Crf and Tac2 (A-P -1.5).
Tumors treated with anti-Flk-1 mAb have increased tumor cell apoptosis, reduced tumor cell proliferation, and increased tumor necrosis. s.c. Tumors treated.
Manipulation of Sox11 shifts the abundance of differentiated neurons and apical progenitors. Manipulation of Sox11 shifts the abundance of differentiated.
At P23, dendritic spine density on L2/3 pyramidal cells in PirB−/− visual cortex is similar to that of PirB+/+. At P23, dendritic spine density on L2/3.
Maximum intensity confocal projections of ventral OBs at different developmental stages stained with anti-KLH and anti-SV2 antibodies (as indicated); the.
Dendritic morphology of hippocampal CA1 neurons from wild-type and cbdnf ko animals. Dendritic morphology of hippocampal CA1 neurons from wild-type and.
Fig. 3. HERV-K–induced neuronal toxicity in vivo.
Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.
Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.
Restricted neurite outgrowth in explant cultures of Nmnat2gtE/gtE DRGs and SCGs at different embryonic stages. Restricted neurite outgrowth in explant.
BDNF protein is expressed in neurons and astrocytes of hippocampus after pilocarpine-induced SE. A, Representative confocal images of hippocampal subfields.
Presentation transcript:

Defects in neuronal and glial process outgrowth Defects in neuronal and glial process outgrowth. a–c , Sections through the cerebral cortex of P0 animals of the indicated genotype were stained with antibodies to MAP2 (green), to reveal dendrites. Defects in neuronal and glial process outgrowth. a–c , Sections through the cerebral cortex of P0 animals of the indicated genotype were stained with antibodies to MAP2 (green), to reveal dendrites. Note that dendrite morphology was severely affected in Itgb1-CNSko mice only. d–l , Dissociated cells from the cerebral cortex of P0 animals of the indicated genotype were plated onto PDL/LN substrates and cultured for 1 d (1div) or 5 d (5div). The cultures were stained with antibodies to MAP2 or GFAP (brown), as indicated. d–f , In cultures containing cells from wild-type mice, neurite outgrowth was evident at 1div and more pronounced by 5div. Many glial cells also formed extensive projections (arrows in f ). g–i , Neurite outgrowth and the formation of glial processes was severely impaired in primary cultures containing cells from Itgb1-CNSko mice. j–l , Neurite outgrowth and the formation of glial processes were restored in cultures with cells from Itgb1-NEXko mice. m , n , The length of the glial processes and neurites was determined. Values indicated the mean and SD. A Student's t test was performed (***p < 0.01). Scale bars: a–c , 50 μm; d–l , 76 μm. Richard Belvindrah et al. J. Neurosci. 2007;27:13854-13865 ©2007 by Society for Neuroscience