This month in Gastroenterology Eugene B. Chang  Gastroenterology  Volume 126, Issue 4, Pages 947-949 (April 2004) DOI: 10.1053/j.gastro.2004.02.010

Figure 1 Response rates of patients with Crohn’s disease treated with either MRA 8 mg/kg biweekly (M2W), MRA 8 mg/kg/placebo alternately, biweekly (M4W), or placebo biweekly. Gastroenterology 2004 126, 947-949DOI: (10.1053/j.gastro.2004.02.010)

Figure 2 (A) Schematic representation of the 4D-ELF instrument: Xe, xenon lamp; Hg, mercury lamp; C, condenser; L, lenses; A, apertures; P, polarizers; M, mirrors; B, beam splitter; SS, sample stage; SP, spectrograph; CCD, CCD camera; Lc, calibration lenses; Ac, calibration apertures. (B ) representative 4D-ELF fingerprints from rats killed at 2 weeks after the AOM or saline injection. The color represents intensity of backscattering light. The horizontal axis is the wavelength of the backscattering light. The vertical axis is the backscattering angle. (a ) Saline-treated rat, proximal colon; (b ) AOM-treated rat, proximal colon; (c ) saline-treated rat, distal colon; and (d) AOM-treated rat, distal colon. As demonstrated, even at this very early time point, AOM treatment had a dramatic effect on 4D-ELF signatures in the distal colon. However, in the proximal colon, the changes attributable to AOM treatment were quite subtle. Gastroenterology 2004 126, 947-949DOI: (10.1053/j.gastro.2004.02.010)

Figure 3 Reversal of experimental (bile duct ligation-induced) fibrosis by in vivo MMP8 gene delivery (AdMMP8). Masson trichromic staining (100×) showing cirrhotic nodules surrounded by thick fibrotic bands (in blue) even at the end of treatment with control virus vector (AdGFP). However, animals treated with AdMMP8 show only thin fibrous bands consisting of connective tissue proteins. Gastroenterology 2004 126, 947-949DOI: (10.1053/j.gastro.2004.02.010)