Jacqueline M. Achkar, Arturo Casadevall Cell Host & Microbe

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Antibody-Mediated Immunity against Tuberculosis: Implications for Vaccine Development Jacqueline M. Achkar, Arturo Casadevall Cell Host & Microbe Volume 13, Issue 3, Pages 250-262 (March 2013) DOI: 10.1016/j.chom.2013.02.009 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Interpretation of the Potential Function of Pro- and Anti-Inflammatory Antibodies against M.tb in the Context of the Damage-Response Framework by Casadevall and Pirofski (A) Potential effects of a proinflammatory antibody with enhanced inflammation leading on the one hand to the improvement from disseminated/miliary TB in an immunocompromised host (left) to localized granuloma formation, and on the other hand to progression from granuloma to caseous necrosis in the more immunocompetent host (right). (B) Potential effects of an anti-inflammatory antibody leading to worsening TB dissemination in the immunocompromised host who has already reduced inflammation (left), but improved containment of local disease from caseous necrosis to granuloma formation in the more immunocompetent host with a strong inflammatory response (right). LTBI, latent TB infection. Cell Host & Microbe 2013 13, 250-262DOI: (10.1016/j.chom.2013.02.009) Copyright © 2013 Elsevier Inc. Terms and Conditions