George M Butterstein, Ph.D., V.Daniel Castracane, Ph.D.

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Presentation transcript:

Effect of particle size on the prolonged action of subcutaneous danazol in male and female rats George M Butterstein, Ph.D., V.Daniel Castracane, Ph.D. Fertility and Sterility Volume 74, Issue 2, Pages 356-358 (August 2000) DOI: 10.1016/S0015-0282(00)00651-8

Figure 1 Serum LH levels in castrated male rats after a single subcutaneous injection of vehicle, danazol with a particle size of 2.05 μm (particle #1), or danazol with a particle size of 5.2 μm (particle #2). The larger-particle danazol suppressed LH levels for the entire 35 days of the study (P<.001), whereas LH levels increased after 25 days in animals that received the smaller-particle danazol. Butterstein. Effect of danazol particle size. Fertil Steril 2000. Fertility and Sterility 2000 74, 356-358DOI: (10.1016/S0015-0282(00)00651-8)

Figure 2 Estrous cycle length in female rats that received danazol with a particle size of 2.05 μm (particle #1), or danazol with a particle size of 5.2 μm (particle #2). The normal estrous cycle of 4.8 ± 0.40 days was prolonged to 38.7 ± 0.95 days (P<.001) after injection of larger-particle danazol, whereas smaller-particle danazol inhibited estrus for 25.5 ± 3.1 days. The results of Tukey-Kramer post hoc analysis comparing all mean differences (particle #1 vs. particle #2, particle #1 vs. vehicle, and particle #2 vs. vehicle) were significant (P<.05). Butterstein. Effect of danazol particle size. Fertil Steril 2000. Fertility and Sterility 2000 74, 356-358DOI: (10.1016/S0015-0282(00)00651-8)