Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and.

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Presentation transcript:

Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and Vβ5.1 chains Andreas Kerstan, MD, Niklas Beyersdorf, MD, Johanna Stoevesandt, MD, Axel Trautmann, MD Journal of Allergy and Clinical Immunology Volume 130, Issue 4, Pages 994-996.e3 (October 2012) DOI: 10.1016/j.jaci.2012.05.010 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 TCR Vβ use in memory Treg and memory T cells. A, Gating approach for CD4+CD25+Foxp3+ T cells. Percentages of CD25+ and Foxp3+ T cells are indicated, respectively. cts, Counts. B, Significant increase in Vβ2- and Vβ5.1-expressing memory Treg cells after 1 month (T1) of VIT. N = 20 (T0 and T1) and n = 9 (T6). *P < .05 (repeated-measures ANOVA, followed by the Tukey-Kramer test). Journal of Allergy and Clinical Immunology 2012 130, 994-996.e3DOI: (10.1016/j.jaci.2012.05.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 TCR Vβ chain expression of CD3+CD4+ T cells. TCR Vβ repertoire was analyzed by costaining with 24 different anti-TCR Vβ antibodies before and 1 month after starting VIT. Each circle represents 1 patient. Dashes indicate means. Journal of Allergy and Clinical Immunology 2012 130, 994-996.e3DOI: (10.1016/j.jaci.2012.05.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 TCR Vβ3, Vβ8, Vβ13.1, and Vβ17 use of T-cell subsets. TCR Vβ chains were determined before (T0), 1 month (T1), or 6 months (T6) after starting VIT. N = 20 (T0 and T1) and n = 9 (T6). Each circle represents 1 patient. Dashes indicate means. Journal of Allergy and Clinical Immunology 2012 130, 994-996.e3DOI: (10.1016/j.jaci.2012.05.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Individual changes in Vβ2 and Vβ5.1 frequency distribution of memory Treg and memory T cells after 1 month of VIT (T1) compared with the start of VIT (T0). Change (Δ) in expression is depicted in 1% intervals. Journal of Allergy and Clinical Immunology 2012 130, 994-996.e3DOI: (10.1016/j.jaci.2012.05.010) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions