Fig 3.1 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017.

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Fig 3.1 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Table 3.1 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Table 3.2 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.2 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.3 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Amino Acid Side Chains: Where the Action is! The amino acids are classified according to the chemical character of the R-group attached to the -carbon Important Criteria: Polar or Nonpolar side chains Acidic or Basic Charged or uncharged Polar residues

Side Chain Classification Nonpolar (hydrophobic) Amino Acids G, A, V, L, I, P, F, W, M These amino acids have aliphatic side chains Phenylalanine and Tryptophan are aromatic Proline is cyclic Induces turns in proteins

Side Chain Classification Polar, Uncharged Amino Acids S, T, Y, C, N, Q S, T, Y have hydroxyl groups (-OH) C has a sulfhydryl (-SH) N and Q have amide side chains Uncharged at neutral pH

Side Chain Classification Acidic Amino Acids D and E have carboxylic acids on their side chains The side chains are negatively charged at neutral pH This means the pKa’s of the side chains are less than 7

Side Chain Classification Basic Amino Acids H, K and R have side chains that are positively charged at neutral pH Because these side chains have basic groups, they accept protons at pH values lower than the pKa of the side chain

But Dr. Hurlbert, there are so many, they’re like Pokemon and I hate Pokemon. Sorry, you still gotta catch ‘em all. At the very least you MUST know S, C, D, E, H, K, R Why? Because they do things, the rest don’t.

Fig 3.4 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.5 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.6 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.7 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Table 3.3 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.8 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017

Fig 3.13 Reproduced from: Biochemistry by T.A. Brown, ISBN: 9781907904288 © Scion Publishing Ltd, 2017