Differential induction of maturation by the different forms of CpG correlates with their ability to promote T cell activation. Differential induction of.

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Differential induction of maturation by the different forms of CpG correlates with their ability to promote T cell activation. Differential induction of maturation by the different forms of CpG correlates with their ability to promote T cell activation. Purified PDCs (8 × 104 cells) were stimulated with ISS alone or combined with PMXB for 24 h. Naive CFSE-labeled allogenic CD4+ T cells were added (1:2) and incubated for an additional 4 d. Cells were gated on CD3 and examined for the frequency of dividing cells based on CFSE dilution by flow cytometry. (A) One representative and (B) averages of 16 independent MLR reactions are shown. **, P < 0.01; ***, P < 0.001. Cristiana Guiducci et al. J Exp Med 2006;203:1999-2008 © 2006 Rockefeller University Press