Substrate oxidation and contractile performance of Akita hearts

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Presentation transcript:

Substrate oxidation and contractile performance of Akita hearts Substrate oxidation and contractile performance of Akita hearts. 24-week-old wild-type and Akita mouse hearts were perfused in the isolated working mode without insulin (basal) or in the presence of 1 nmol/l insulin (n = 4–5). Substrate oxidation and contractile performance of Akita hearts. 24-week-old wild-type and Akita mouse hearts were perfused in the isolated working mode without insulin (basal) or in the presence of 1 nmol/l insulin (n = 4–5). A: Left ventricular–developed pressure (LVDevP). B: Cardiac output. C: Cardiac power. D: Palmitate oxidation. E: Glucose oxidation. F: Glycolysis. G: Oxygen consumption. H: Cardiac efficiency. *P < 0.05 vs. wild type, ΨP < 0.05 vs. without insulin. Heiko Bugger et al. Diabetes 2008;57:2924-2932 ©2008 by American Diabetes Association