Volume 54, Issue 4, Pages 1290-1295 (October 1998) Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?  Toshio Miyata, Min-Xin Fu, Kiyoshi Kurokawa, Charles van Ypersele De Strihou, Suzanne R. Thorpe, John W. Baynes  Kidney International  Volume 54, Issue 4, Pages 1290-1295 (October 1998) DOI: 10.1046/j.1523-1755.1998.00093.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Plasma Nε-(carboxymethyl)lysine (CML), pentosidine, and MDA-lysine levels in normal and hemodialysis subjects. CML (A), pentosidine (B), and malondialdehyde (MDA)-lysine (C) levels in acid hydrolysates of plasma from normal subjects (Group I, N = 9), non-diabetic hemodialysis patients (Group II, N = 25), and diabetic hemodialysis patients (Group III, N = 21), were determined by GC/MS or HPLC assay (detailed in Methods section). Data are expressed as means ± sd.*P < 0.0001 versus normal subjects. NS is not significant. Kidney International 1998 54, 1290-1295DOI: (10.1046/j.1523-1755.1998.00093.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 (A) Correlation between plasma CML and fructoselysine in hemodialysis patients. Plasma CML levels were not correlated with those of fructoselysine in hemodialysis subjects (N = 46, r = 0.186, P = 0.216). The equation of the line is y = 3.022x + 2.345. (B) Correlation between plasma CML and pentosidine in hemodialysis patients. Plasma CML levels were correlated with those of pentosidine in hemodialysis subjects (N = 46, r = 0.430, P < 0.01). The equation of the line is y = 34.86x + 1.07. Kidney International 1998 54, 1290-1295DOI: (10.1046/j.1523-1755.1998.00093.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 (A) Correlation between plasma pentosidine and MDA-lysine in hemodialysis patients. Plasma pentosidine levels were not correlated with those of MDA-lysine in hemodialysis subjects (N = 46, r = 0.097, P = 0.522). The equation of the line is y = 0.00013x + 0.033. (B) Correlation between plasma CML and MDA-lysine in hemodialysis patients. Plasma CML levels were correlated with those of MDA-lysine in hemodialysis subjects (N = 46, r = 0.320, P < 0.05). The equation of the line is y = 0.035x + 0.023. Kidney International 1998 54, 1290-1295DOI: (10.1046/j.1523-1755.1998.00093.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1290-1295DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1290-1295DOI: (10.1046/j.1523-1755.1998.00093.x) Copyright © 1998 International Society of Nephrology Terms and Conditions